Kurt Zouma and Nikola Vlasic make their full Premier League debuts for West Ham. Vlasic or Jarrod Bowen will play up front instead of the suspended Michail Antonio, a like-for-like replacement either way.
The increasingly influential Scott McTominay returns from injury for Manchester United, which means a slight reshuffle and the omission of Jadon Sancho.
West Ham (4-2-3-1, positions of the front four tbc) Fabianski; Coufal, Zouma, Ogbonna, Cresswell; Soucek, Rice; Vlasic, Fornals, Benrahma; Bowen.
Substitutes: Areola, Dawson, Diop, Fredericks, Masuaku, Lanzini, Noble, Kral, Yarmolenko.
Manchester United (4-2-3-1) de Gea; Wan-Bissaka, Varane, Maguire, Shaw; McTominay, Fred; Greenwood, Fernandes, Pogba; Ronaldo.
Substitutes: Heaton, Bailly, Dalot, Lingard, Mata, Matic, van de Beek, Martial, Sancho.
Referee Martin Atkinson.